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Open access

Discovery of a Cell-Permeable Gi-Signaling Inhibitor

A. Naimi Tim Berger Philipp Dahlhaus M. Rossol Jonas Mühle Wieland Steinchen G. Bange Uwe Linne P. Stincone Xavier Deupi G. Schertler Lars Jürgenliemke E. Kostenis J. Kockskämper Daniel Hilger Daniel Petras R. Reher
Aug 2026 · bioRxiv · 0 citations · 16 references
Biology

TL;DR

N-hydroxyapiosporamide (NHAP) is established as a first-in-class Gi-selective inhibitor, providing a cell-permeable chemical scaffold for the optimization of next-generation agents to control Gi-signaling in cell-based systems and, ultimately, to target Gαi1-driven pathologies.

DOI Semantic Scholar
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