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Author

J. Kockskämper

2 papers indexed here

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Review Open access Oct 2026

Dual Role of CACNA1C/CaV1.2 in Cardiac and Neuropsychiatric Disease

The CACNA1C gene encodes the α1C subunit of voltage-gated CaV1.2 calcium channels, serving many pivotal functions throughout the body, including in the heart and brain. Clinical and genetic evidence implicates altered expression and/or function of CACNA1C/CaV1.2 in both cardiac and neuropsychiatric disease, including h...

David Königstein, Theresa M. Kisko, Susanne Michels et al. · 0 citations
Open access Aug 2026

Discovery of a Cell-Permeable Gi-Signaling Inhibitor

N-hydroxyapiosporamide (NHAP) is established as a first-in-class Gi-selective inhibitor, providing a cell-permeable chemical scaffold for the optimization of next-generation agents to control Gi-signaling in cell-based systems and, ultimately, to target Gαi1-driven pathologies.

A. Naimi, Tim Berger, Philipp Dahlhaus et al. · 0 citations

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