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Author

Uwe Linne

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Open access Jul 2026

A human-specific long noncoding RNA regulator of antigen-presenting cell viability and antimicrobial defense.

SAILR is identified as a central regulator in linking macrophage survival to host-pathogen interaction and disease pathophysiology, and interacts with the antiapoptotic adaptor protein 14-3-3β to support macrophage survival.

A. Westermann, Alexandra Schock, Diyaa Al Din Ashour et al. · 2 citations
Open access Aug 2026

Molecular insights into the promiscuous Ap4N hydrolase YqeK

These findings establish YqeK as a central regulator of dinucleotide homeostasis and RNA metabolism and provide the structural framework for Ap4N recognition by HD-domain phosphohydrolases.

Renuka Dharani Shivakumar, Natalie Happel, Fabiana Burchert et al. · 0 citations
Open access Aug 2026

Discovery of a Cell-Permeable Gi-Signaling Inhibitor

N-hydroxyapiosporamide (NHAP) is established as a first-in-class Gi-selective inhibitor, providing a cell-permeable chemical scaffold for the optimization of next-generation agents to control Gi-signaling in cell-based systems and, ultimately, to target Gαi1-driven pathologies.

A. Naimi, Tim Berger, Philipp Dahlhaus et al. · 0 citations

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