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AD should be considered a disorder of consciousness and should motivate further investigation into the dimensions of awareness affected by the disorder with implications for treatment and management of people with dementia.
These network-specific, hemisphere-sensitive measures may serve as biomarkers for diagnosis, tracking, and prognosis of cognitive decline, and could inform personalized network-targeted neuromodulation in AD.
This study provided a valuable insight into the heterogeneity of EOAD and LOAD, extending current understanding of the differential involvement of brain regions and highlighting the importance of hypothalamic involvement as a potential target for further investigation in conjunction with clinical assessment.
Trans transcranial magnetic stimulation with electromyography is used to investigate mechanisms of motor cortical excitability in biomarker-positive early-AD participants and 72 cognitively unimpaired age-matched adults and shows that early-AD participants have increased motor cortical excitability, related to cognitio...
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