This study provided a valuable insight into the heterogeneity of EOAD and LOAD, extending current understanding of the differential involvement of brain regions and highlighting the importance of hypothalamic involvement as a potential target for further investigation in conjunction with clinical assessment.
Findings support the utility of plasma p-tau217 as a biomarker in this population and underscore the role of sleep processes in the relationship between neurodegenerative pathology and cognition in older adults with epilepsy.
R. Sarkis, Hyun-Sik Yang, Lei Liu et al.· Neurology· 0 citations
OBJECTIVE
Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia after Alzheimer's disease (AD), with significant pathological overlap between the two conditions. However, the impact of Alzheimer's co-pathology on basal forebrain (BF) atrophy and its relationship with neurodegeneration and...
Daniele Urso, Thomas Giannelli, B. Tafuri et al.· Annals of Neurology· 0 citations
A practical multi-axis framework comprising clinical phenotype, AD biological context (AD pathology plus co-pathologies and molecular modifiers), network topography (regional patterns) and tempo (rate of clinical and biomarker progression) is proposed to reduce diagnostic mismatches, make cohorts more comparable and su...
L. Grinberg, M. Murray· Nature Reviews Neurology· 0 citations
Cognitive and CSF phenotype of LO-TLE with normal CSF AD biomarkers is characterized by distinct cognitive and biological features compared with MCI-AD, suggesting a disease process independent of AD.
Alessia Casarini, Alice Ballerini, Riccardo Maramotti et al.· Neurology· 0 citations
The study revealed structural brain abnormalities in aMCI, characterized by reduced hippocampal and hippocampal subfield volumes, as well as amygdala volume reduction, while other subcortical structures were relatively preserved.
N. Cherkasov, A. Tomyshev, E. Abdullina et al.· medRxiv· 0 citations