M. Filippi

Restoring locomotion in motor-complete spinal cord injury via trunk-mediated control using a commercial epidural spinal cord stimulator.

BACKGROUND Spinal cord stimulation is emerging as a novel approach to restore movement in patients affected by spinal cord injury. Recent advances have shown restoration of locomotion in patients with complete motor lesions using sophisticated new systems including a brain machine interface. Despite the great potential...

Use of MRI in neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease - MAGNIMS consensus recommendations.

Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility

Inhibitory neurons emerged as a key target cell type for MS-associated variants, with seven loci, including STAT3, displaying altered expression only in these cells, suggesting that MS susceptibility may reflect reduced central nervous system resilience to inflammatory challenges.

Spatiotemporal deep learning for early detection of isolated REM sleep behavior disorder and Parkinson's disease using functional MRI data.

StDNN has the potential of stDNN to differentiate between iRBD, PD, and controls using rs-fMRI data, and demonstrates over 80% accuracy in differentiating healthy controls from iRBD.

Altered perivascular space diffusivity dynamics in motor neuron disease

Abstract Converging evidence supports a key pathogenic role of the glymphatic system in the accumulation of pathological aggregates in several central nervous system proteinopathies, including amyotrophic lateral sclerosis and other motor neuron diseases. This study aimed to investigate potential glymphatic impairment...

Different hypothalamic regions in late-onset Alzheimer's disease and aging: involvement and links with cognitive and non-cognitive features.

This study provided a valuable insight into the heterogeneity of EOAD and LOAD, extending current understanding of the differential involvement of brain regions and highlighting the importance of hypothalamic involvement as a potential target for further investigation in conjunction with clinical assessment.