Author

G. Filocamo

2 papers indexed here

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Open access Oct 2026

Structure-Based Design of HDAC6 Inhibitors Targeting the L2 Pocket: Modulating Autophagy and Liquid−Liquid Phase Separation in Lung Cancer

X-ray co-crystal structures of second-generation inhibitors 19b and 20b within zHDAC6 CD2 confirmed that these compounds behave as highly potent HDAC6 inhibitors with the ability to engage the S531 residue in the L2 loop HDAC6 catalytic domain.

Simona Barone, Abraham Eafa, I. Bello et al. · Journal of Medicinal Chemist... · 0 citations

#protein folding Sep 2026

Abstract A006: Identification of a novel, safety-engineered ADC directed against FGFR4 for the treatment of Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and young adults. While low risk disease has a 90% survival probability, metastatic RMS has a dismal prognosis. Treatment options include chemotherapy and local therapy (surgery, radiotherapy) but suffer from serious long-term side effects. The...

C. Steinkühler, Mirko Brunetti, Cristina Maria Depalma et al. · Cancer Research · 0 citations