IRE1α undergoes a dynamic filament assembly cycle governed by unfolded proteins and BiP
The endoplasmic reticulum is a major hub of protein synthesis, modification and trafficking that relies on the Unfolded Protein Response (UPR) to balance its folding capacity. IRE1, the most conserved of the UPR sensors, undergoes a change in oligomeric state upon activation that propagates the stress signal from the E...
Melissa Méndez-Moran, Maxence Le Vasseur, Daniel Itzhak et al.
· bioRxiv · 0 citations