Structural insights into Cas9 inhibition by AcrIIA17 via bridge helix interaction
The crystal structure of AcrIIA17 is presented and its mechanism of Staphylococcus aureus Cas9 (SauCas9) inhibition is elucidated, identifying AcrIIA17 as an Acr protein that targets the Cas9 BH domain and reveal the BH domain as a regulatory checkpoint in Cas9 activation.
G. Kim, Hyo Been Jin, Yong-Jun Kang et al.
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