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Author

G. Kurgan

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Open access Aug 2026

UNCOVERseq enables sensitive and controlled gene editing off-target nomination across CRISPR-Cas modalities and systems

An in-cell method that sensitively detects rare off-target edits, benchmarks performance across editors, and improves risk assessment in therapeutic cells is presented, establishing UNCOVERseq as a robust framework for informed off-target risk assessment in translational gene-editing systems.

Kyle J. Kinney, Kun Jia, He Zhang et al. · 3 citations
Open access Aug 2026

Single-cell and in vivo profiling reveal heterogeneous and organ-specific CRISPR-Cas9 off-target and translocation outcomes

It is shown that off-target editing and translocations vary widely between individual cells and organs, motivating the development of more sensitive and organ-specific safety assays for CRISPR therapies.

Alexandra Madsen, Niklas Selfjord, M. Martinez-Lage et al. · 0 citations