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G. Palmisano

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Open access Sep 2026

Carnosine Potentiates a Compensatory Mitochondrial–Synaptic Proteomic Response in the ALS Cerebellum

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron degeneration and chronic neuroinflammation in the brain and spinal cord, involving complex interactions between neurons and immune cells. Carnosine (β-alanyl-L-histidine) has pathophysiological relevance d...

Hellen P. Valério, Valeria Oliveira, Stephanie Y. Ferreira et al. · 0 citations
Open access Aug 2026

STEP-PTMs: Sequential TMT-based Enrichment and Profiling of Post-Translational Modifications

Application of STEP-PTM to TMT16-plex cerebral brain organoids enabled the quantification of 10,413 proteins, 2,969 metabolites, 19,655 phosphopeptides, 28,876 peptides containing reversibly modified cysteines, 9,723 peptides containing free cysteines, 1,716 intact sialylated N-linked glycopeptides and 771 lysine-acety...

Lucrezia Criscuolo, S. B. Elmkvist, Arkadiusz Nawrocki et al. · 0 citations

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