Author

Geraldine Zimmer-Bensch

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Open access Aug 2026

Disease-Associated Mutations Impact DNA Methyltransferase 1 Function through Dynamic Allosteric Effects and Solvent Exposure

An extensive molecular dynamics investigation of wild-type DNMT1 and its mutants associated with ADCA-DN and HSAN1E sheds light on the molecular mechanisms underlying ADCA-DN and HSAN1E, which could inform the development of therapies.

Song Xie, Can Bora Yildiz, Paolo Ruggerone et al. · Journal of Chemical Theory a... · 0 citations

Open access Jul 2026

A new set of DNA methylation variants in the human genome show predominant tissue-specificity and sensitivity to reprogramming with a potential for disease susceptibility

MeVars have postzygotic origins with an ability to ‘reset’ during reprogramming, adding a new dimension in the form of epigenetic diversity and its relevance to disease susceptibility in humans.

Anuhya Anne, Lov Kumar, Monica Singh et al. · bioRxiv · 0 citations