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A new set of DNA methylation variants in the human genome show predominant tissue-specificity and sensitivity to reprogramming with a potential for disease susceptibility

Anuhya Anne Lov Kumar Monica Singh Sumana Choudhury Satarupa Das Geraldine Zimmer-Bensch Debashree Bandyopadhyay K. N. Mohan

Jul 2026 · bioRxiv · 0 citations · 47 references

Biology

TL;DR

MeVars have postzygotic origins with an ability to ‘reset’ during reprogramming, adding a new dimension in the form of epigenetic diversity and its relevance to disease susceptibility in humans.

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