Author

Giulia Palermo

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#gene editing Open access Oct 2026

Visualizing the Atomic-Level Impact of Anti-CRISPR II–C1 Inhibition on Geo Cas9 with Integrated Structural Biophysics

Abstract Anti-CRISPRs (Acrs) are small protein inhibitors of CRISPR-Cas effectors that originate from the translated genetic material of bacteriophage. Harnessing the natural ability of Acrs to bind and disrupt CRISPR-Cas editing can provide enhanced spatiotemporal control of gene editing. Recent studies have revealed...

Alexa L Knight, Helen B Belato, Praise Lasekan et al. · JACS Au · 0 citations

#gene editing Open access Oct 2026

A cryptic binding pocket regulates the metal-dependent activity of Cas9

Abstract Cas9 is a metal-dependent nuclease used for genome editing across diverse cells and organisms exhibiting distinct ionic environments, yet how metal ions regulate its catalytic function, and consequently its editing efficiency remains unclear. Here, molecular simulations, Markov state models, and mixed quantum–...

Mohd Ahsan, Alexa L Knight, Aakash Saha et al. · Nature Communications · 2 citations

#gene editing Open access Oct 2026

Transposon end recognition and pairing by I-F3 CRISPR-associated transposase

To develop gene therapy tools based on CRISPR-associated transposons (CASTs), it is essential to define how transposon ends are recognized and paired during transposition. Transposon 7 (Tn7)–like transposons typically contain asymmetric left- and right-end sequences that flank and define DNA cargo. However, how the tra...

Vinh H. Truong, Darcie J. Miller, Shirin Fatma et al. · Science Advances · 0 citations