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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Giuseppe Rizzo

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3 papers indexed here

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Open access Sep 2026

Type I IFN signaling shapes subset-specific monocyte fates in the injured myocardium

Monocytes and macrophages promote tissue repair following myocardial infarction, but the mechanisms tuning their effector functions remain elusive. While macrophages are essential in clearing debris and resolving inflammation, they can also contribute to uncontrolled inflammation and provoke additional damage. Thus, fa...

Ecem T. Sakalli, Giuseppe Rizzo, A. Zernecke et al. · 0 citations
Open access Aug 2026

TREM2 drives accumulation of pro-scarring monocyte-derived macrophages in the infarcted myocardium

Myocardial infarction is a leading cause of death and disability worldwide. Ischemic injury leads to irreversible loss of cardiomyocytes, the contractile cells of the heart, and formation of a fibrotic scar. After infarction, macrophages massively infiltrate the heart and orchestrate the tissue repair process by removi...

Giuseppe Rizzo, Marie Piollet, T. Krammer et al. · 0 citations
#gene editing Open access Oct 2026

Redirecting full-length FLT1 expression towards its soluble isoform by targeting alternative polyadenylation promotes postischaemic angiogenesis.

Using this mouse model, it is demonstrated that sFLT1 alone is sufficient for developmental vasculogenesis, whereas the specific loss of flFLT1 enhances reparative revascularization and angiogenesis and improves cardiac recovery after myocardial infarction.

M. Bundalo, Sandra Vorlová, Jessica Ulrich et al. · 0 citations

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