Author

Gonçalo Trindade

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#gene editing Open access Oct 2026

CRISPR–Cas9 Editing of Myeloid Lectins Reveals Target-Dependent Transcriptional Remodeling in Tumor-Associated Macrophages

Tumor-associated macrophages (TAMs) integrate multiple microenvironmental signals, including lectin-mediated recognition of tumor-associated glycans. Although several myeloid lectins have been implicated in tumor–macrophage interactions, their contributions to immunosuppressive TAM phenotypes remain poorly defined. We...

Gonçalo Trindade, M. Pinto, G. Domenici et al. · bioRxiv · 0 citations

Review Open access Sep 2026

Transmembrane lectins in cancer immunity: emerging drivers of myeloid-mediated immunosuppression

This review integrates evidence from tumor glycobiology, myeloid immunology, receptor signaling, experimental models, and therapeutic development to examine how C-type lectin receptors and Siglecs contribute to myeloid-mediated immune suppression.

Gonçalo Trindade, Angelina S. Palma, Catarina Brito · Frontiers in Immunology · 2 citations

Open access Sep 2026

Myeloid Lectin Profiling Identifies SYK as a Targetable Signaling Node for Remodeling Immunosuppressive Tumor-Associated Macrophages in Breast Cancer

A myeloid lectin framework associated with BC immunosuppression is defined and SYK is identified as a candidate targetable node for remodeling TAMs.

Gonçalo Trindade, G. Domenici, M. Pinto et al. · bioRxiv · 0 citations