Regulation of the human voltage-gated proton channel by membrane sterols
This work identified the key molecular determinant in the hHv1 channel that mediates cholesterol inhibition and also provided a mechanism linking the conversion between demosterol and cholesterol by DHCR24 to pH homeostasis in many cells, such as phagocytes, cardiomyocytes, neurons and microglial cells.
Shuo Han, R. Duan, Sarah Applewhite et al.
· bioRxiv · 0 citations