Aug 2026
A single-cell study of transcription and RNA splicing in MDD and ALC
Guang-Lei Chen, Xing Zhu, Can-Can Chu et al.
· European Archives of Psychia... · 0 citations
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Open access
Aug 2026
Potential mechanisms by which microbiota-accessible carbohydrates regulate hepatic lipid metabolism in MAFLD via the gut-liver axis
Overall, MACs may influence MAFLD progression through coordinated regulation of gut microbiota composition, gut-derived metabolites, and intestinal barrier function, but their clinical translation still requires further validation through human studies and comprehensive safety evaluation.
Jing-Yi Peng, Xiao-Jiao Gao, Guang-Lei Chen et al.
· Frontiers in Microbiology · 0 citations
Open access
Jul 2026
Genomic structural equation modeling uncovers shared genetic architecture and comorbidity mechanisms of lung function decline.
The mvLung GWAS characterise shared genetic signals across the included traits and nominate candidates for functional follow-up and drug-target analyses showed pathway-level concordance with previously studied cardiopulmonary drug classes.
Guang-Lei Chen, Yun-Zhi Chen, Can-Can Chu et al.
· Scientific Reports · 0 citations
The role of lysine acylation in metabolic dysregulation and inflammatory responses within the hepatic immune microenvironment of MASLD
Overall, lysine acylation is closely associated with metabolic disturbances, hepatic inflammation, and fibrogenic processes in MASLD and is highlighted regarding the potential of lysine acylation as a biomarker and therapeutic target.
Jing-Yi Peng, Ankangxin Yan, Guang-Lei Chen et al.
· Frontiers in Immunology · 0 citations