Author

Guang-Yi Fan

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Open access Aug 2026

A cross-vertebrate single-cell and spatial atlas reveals evolutionary trajectories of gastrointestinal cellular innovation.

The cellular innovations underlying vertebrate gastrointestinal diversification remain largely unknown. Here, we constructed a single-cell and spatial transcriptomic atlas comprising nearly 1 million cells from 10 species, spanning 500 million years of vertebrate evolution. Analysis of conserved gene co-expression modu...

Lidong Guo, Bai-Chuan Tong, Xiao-Min Gao et al. · Cell Genomics · 0 citations

#gene editing Review Open access Sep 2026

Zebrafish in the era of single-cell and spatial transcriptomics: a new paradigm for central nervous system drug discovery from natural products.

Natural products (NPs) represent a an important chemical source for CNS therapeutics for central nervous system (CNS) therapeutics, yet elucidating their complex, multitarget mechanisms remains a major challenge. Zebrafish have emerged as a powerful vertebrate model bridging the translational gap between in vitro assay...

Yida Huang, Xiang Liu, Guang-Yi Fan et al. · British Journal of Pharmacol... · 0 citations