Celastrol alleviates synovial inflammation and joint destruction in rheumatoid arthritis in association with Nrf2/HO-1/GPX4 pathway activation
It is suggested that CEL alleviates synovial inflammation and joint injury in experimental RA in association with Nrf2/HO-1/GPX4 pathway activation and suppression of TNF-α-stimulated rat FLS activation, supporting further investigation of CEL as a candidate antioxidant-oriented therapeutic agent for RA.