Aug 2026· Molecular and Cellular Biochemistry· Vol 481, pp. 5101 - 5112· 0 citations· 29 references
Medicine
TL;DR
It is suggested that CEL alleviates synovial inflammation and joint injury in experimental RA in association with Nrf2/HO-1/GPX4 pathway activation and suppression of TNF-α-stimulated rat FLS activation, supporting further investigation of CEL as a candidate antioxidant-oriented therapeutic agent for RA.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation and progressive joint damage. This study investigated the role of microRNA-223 (miR-223) in RA and evaluated the therapeutic effects of triptolide (Tri), a diterpenoid epoxide derived from the traditional Chinese medicina...
Xiao-Bao Liu, Y. Xiang, Jia-Hao Yang et al.· The American Journal of Chin...· 0 citations
Findings support a prophylactic protective effect of sabinene against CFA-induced arthritis associated with reduced inflammation, improved antioxidant status, and modulation of inflammasome-related gene expression.
Kanwal Asif, Ambreen Malik Uttra, Arham Shabbir et al.· Biomolecules & biomedicine· 0 citations
Nitazoxanide (NTZ), an FDA-approved anti-parasitic drug, has shown anti-inflammatory effects in rheumatoid arthritis (RA) fibroblast-like synoviocytes, yet its impact on immune cell function and its potential synergy with methotrexate (MTX) remains unclear. In this study, using a murine collagen-induced arthritis (CI...
Chang-Hong Li, Xiao-Li Chen, Yi-Jun Han et al.· Frontiers in Pharmacology· 0 citations
Rheumatoid arthritis (RA) is a chronic autoimmune disease with progressive joint damage, functional disability and systemic comorbidity. Available therapies are not satisfactory, including low rates of remission and about 30% of patients with poor response to first-line treatment. Thus, more effective therapeutic s...
Jun Cai, Yong-Gui Cai, Jing Luo et al.· Frontiers in Pharmacology· 0 citations
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, progressive bone erosion, and persistent pain, with limited therapeutic options for comprehensive disease control. Growth differentiation factor 15 (GDF15), a stress-responsive cytokine, has been implicated in i...
Li-Juan Mao, Haoran Huang, Zhen Shao et al.· International Immunopharmaco...· 0 citations
Background Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by severe synovial inflammation, joint deformities, and progressive tissue destruction. Celastrol (Cel), a natural triterpenoid with anti-inflammatory and antioxidant activity, is a promising therapeutic candidate for RA; however, its a...
Ji-Quan Shen, Chang-Jian Zhou, Xing-Gao Wang et al.· Frontiers in Immunology· 0 citations
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