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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

H. Kvartsberg

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Open access Aug 2026

Big tau and brain-derived tau reveal peripheral and central nervous system involvement in neuropathies

INTRODUCTION: Biomarkers for monitoring disease activity and treatment response in peripheral neuropathies remain limited. Big tau, a high-molecular-weight isoform of tau, is predominantly expressed in the peripheral nervous system (PNS). We investigated serum levels of big tau, brain-derived tau (BD-tau), and neurofil...

L. Martín-Aguilar, F. González-Ortiz, H. Zetterberg et al. · 0 citations
#protein folding Open access Sep 2026

Epitope placement tunes CSF tau biomarkers: Comparison of P-tau217 and BD-tau designs

Results show that, irrespective of the partner antibody, phosphorylated tau assays are more accurate than assays that also measure non-phosphorylated forms of the protein in differentiating Aβ + from Aβ − individuals, and indicate that BD-pTau217 may offer superior sensitivity for the early identification of AD patholo...

H. Gleerup, C. S. Musaeus, Cristiano Santos et al. · 0 citations

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