use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans
A conceptual framework is presented for the incorporation of in vitro-derived toxicity data into the risk assessment process and the determination of a proper point-of-departure (PoD) for in vitro-in vivo extrapolation, allowing implementation in risk assessment procedures.
B. Blaauboer, K. Boekelheide, H. Clewell et al.
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