use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans

B. Blaauboer K. Boekelheide H. Clewell Mardas Daneshian M. Dingemans A. Goldberg M. Heneweer J. Jaworska N. Kramer Marcel Leist H. Seibert E. Testai R. Vandebriel J. Yager J. Zurlo

· 0 citations · 118 references

TL;DR

A conceptual framework is presented for the incorporation of in vitro-derived toxicity data into the risk assessment process and the determination of a proper point-of-departure (PoD) for in vitro-in vivo extrapolation, allowing implementation in risk assessment procedures.

Semantic Scholar

View source

Similar papers

Review Open access Sep 2026

Extrapolation steps in quantitative in vitro to in vivo extrapolation to advance in vitro-based chemical risk assessment for human health

The transition towards Next Generation Risk Assessment (NGRA) aims at increasing human relevance and efficiency of chemical risk assessment, by using human-based in vitro and in silico methods. Quantitative in vitro to in vivo Extrapolation (QIVIVE) is central to this approach and enables the derivation of health-based...

M. J. M. Benschop, J. Minnema, E. Kasteel et al. · Current Research in Toxicolo... · 0 citations

Open access Sep 2026

In Vitro Exposure Assessment Improves Hazard Ranking of Bisphenol A Alternatives

In vitro toxicity data can be used for comparative hazard assessment of the problematic plastic chemical bisphenol A (BPA) and its replacement chemicals. Hazard assessment is exclusively based on nominal effect concentrations of the BPA alternatives, but due to their diversity of physicochemical properties and stabil...

L. Henneberger, Sophia Bardehly, Arina Kremser et al. · Chemical Research in Toxicol... · 0 citations

Review Open access Oct 2026

Scoping review of existing in silico and PBK models for humans and rats

Abstract One of EFSA research priority research areas is to better understand the role of toxicokinetic and its implementation into next generation risk assessment. Food ingredients and contaminants often lack data on their absorption, distribution, metabolism and excretion (ADME) properties, which are needed to model...

Christina Drake, A. Roncaglioni, Domenico Gadaleta et al. · EFSA Supporting Publications · 0 citations

Open access Aug 2026

A Decision Tree for Acute Oral Toxicity: Implementing the Last Resort Requirement in Practice.

Acute oral toxicity (AOT) testing is widely used for hazard identification in chemical safety assessment, but traditional animal methods are still implemented despite their scientific limitations and ethical implications. Despite the availability of non-animal methods, regulatory uptake has been inconsistent, also due...

G. Pallocca, P. Bishop, P. Browne et al. · Regulatory toxicology and ph... · 0 citations

Review Open access Aug 2026

PFAS: challenges and scientific perspectives in human health risk assessment.

Five key recommendations for future health risk assessments are concluded, prioritizing PFAS; improving analytical methods; promoting generation of robust data and data gap filling; promoting open science, including the development of shared data infrastructure and cross-institutional knowledge exchange; and strengthen...

J. Kowalczyk, Klaus Abraham, Christina August et al. · Archives of Toxicology · 0 citations

Sep 2026

Improving consistency in regulatory assessment of repeated-dose toxicity studies: an EFSA checklist-based framework for statistical evaluation.

The evaluation of 28- and 90-day repeated-dose toxicity studies in rodents is typically performed at the highest tier of regulatory toxicology. Despite detailed guidance from the European Food Safety Authority (EFSA) and Organisation for Economic Co-operation and Development (OECD), the practical implementation and eva...

S. Favilla, Eugenio Traini, M. Ardizzone et al. · Regulatory toxicology and ph... · 0 citations