Author

Marcel Leist

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Open access Oct 2026

Saccharopine and α-Aminoadipic Acid as Potential Biomarkers for Mitochondrial Stress in Neurons

Redox stress and subsequent metabolic reprogramming are well-known consequences of neuronal exposure to mitochondrial toxicants. Here, we investigated, using human neuronal cultures, how such changes are quantitatively reflected in the patterns of cellular and extracellular amino acids. We asked whether these alteratio...

Anna-Katharina Ückert, Anja Land, R. Pape et al. · Cells · 0 citations

use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans

A conceptual framework is presented for the incorporation of in vitro-derived toxicity data into the risk assessment process and the determination of a proper point-of-departure (PoD) for in vitro-in vivo extrapolation, allowing implementation in risk assessment procedures.

B. Blaauboer, K. Boekelheide, H. Clewell et al. · 0 citations