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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Haiyuan Yu

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#gene editing Open access Oct 2026

Alzheimer's disease target and drug discovery by leveraging multiomics and electronic health data.

Despite prolific genomic data from individuals with Alzheimer's disease (AD), translation into treatments has lagged. Here we applied Mendelian randomization to multiple AD genome-wide association studies and functional multiomics datasets to nominate druggable targets, identifying 19 targets for individuals of Europea...

Yuan Hou, Yi-Chen Li, Peng-Yue Zhang et al. · 0 citations
Review

Prediction of protein–protein interactions and co-complex models with deep learning

This review focuses on three closely related tasks of proteome-wide PPI prediction, PPI interface prediction, and PPI co-complex structure prediction, and discusses how emerging concepts and computation approaches have evolved to shape these fields.

Zizhao Zhang, Yilin Liu, Haiyuan Yu et al. · 0 citations
Open access Jul 2026

POGZ safeguards neuronal gene chromatin architecture and transcription

These results identify POGZ as a G9a/GLP-associated chromatin regulator that protects neurodevelopmental gene domains from heterochromatinization and perinuclear sequestering, preserving 3D architecture and transcription during cortical development.

N. Mariano, Katerina J. Williams, Katie Munechika et al. · 0 citations

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