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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Hakeemah H Al-Nakhle

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Open access Oct 2026

Integrated Multi-Omics Characterization of WASHC2C Reveals Cancer-Specific Molecular, Clinical, Immune, and Cellular Associations

WASHC2C encodes a WASH-complex scaffold implicated in actin remodeling, endosomal organization, and intracellular trafficking, yet its cancer-specific molecular and clinical relevance remains insufficiently defined, particularly in the context of the closely related paralogue WASHC2A. We performed an integrated pan-can...

Hakeemah H. Al-Nakhle · 0 citations
Open access Oct 2026

Integrative Molecular Profiling and Single-Cell Characterization of LHFPL5 Reveal Cancer-Specific Regulatory Features in Clear Cell Renal Cell Carcinoma and Lung Adenocarcinoma

Background and Objectives: LHFPL5 encodes a four-pass transmembrane protein essential for cochlear mechanotransduction, but its molecular behavior in cancer remains poorly defined. We characterized the genomic, epigenetic, transcriptomic, immune, and cellular context of LHFPL5 in clear cell renal cell carcinoma (KIRC)...

Hakeemah H. Al-Nakhle, Zinab O. Doha · 0 citations
Open access Jul 2026

Integrative Clinical and Functional Characterization of the TCF7L2 rs7903146 Variant Reveals Regulatory Mechanisms Linking Genetic Susceptibility to Oxidative Stress in Type 2 Diabetes

Predictive evidence was provided suggesting that rs7903146 may have tissue-specific regulatory relevance and may be indirectly linked to metabolic and WNT/β-catenin signaling pathways, and the proposed regulatory mechanisms require experimental validation.

Ahmed M. Ahmed, Hakeemah H Al-Nakhle, Amjad M. Yousuf et al. · 0 citations
Open access Aug 2026

Tumor-Intrinsic DNA Damage Signaling Is Associated with MHC-I Expression and CD8 Cytotoxic T-Cell Engagement in Triple-Negative Breast Cancer

An exploratory, integrative analysis using single-cell RNA sequencing of TNBC patients operationally stratified into Good and Bad Prognosis groups suggests a framework in which tumor-intrinsic DNA damage signaling is associated with MHC-I antigen presentation upregulation and CD8 cytotoxic T-cell engagement, supporting...

Zinab O. Doha, E. AbuAzzah, Hakeemah H Al-Nakhle · 0 citations

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