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Open access Sep 2026

Genetic evaluation of encorafenib-associated kinases RAF1 and MAPK8 in pancreatic cancer: Exploratory mediation by circulating immune traits

Highlights • Genetically proxied RAF1 and MAPK8 expression was associated with pancreatic cancer risk.• A circulating CD4+ Treg-related phenotype showed a possible partial indirect contribution.• PheWAS detected no broad genetic pleiotropic signals at the prespecified threshold.• The findings support further study of R...

Feng-Chang Lin, Wen-Wen Tu, Rong-Gui Lin et al. · 0 citations

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