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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Hanwen Wang

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#protein folding Sep 2026

Quantitative Systems Pharmacology Model Predicts Enhanced Antitumor Efficacy of Combined Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) and Programmed Cell Death Protein 1 (PD-1) Blockade in a Syngeneic Mouse Model of Breast Cancer

Immune-checkpoint inhibitors targeting PD-1 and CTLA-4 have transformed cancer therapy, yet most patients still fail to respond, and the reasons remain incompletely understood. To dissect this heterogeneity and support translational development, we built a preclinical quantitative systems pharmacology model of α-PD-1...

Yu Zhang, Hanwen Wang, Natsuki Furukawa et al. · 0 citations

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