Review
Open access
Sep 2026
Decoding cell–cell communication in spatial transcriptomics: mechanistic insights, modeling constraints, and analytical caveats
This review examines recent methodological developments in CCC inference from ST data, focusing on how statistical, optimal transport, and deep learning frameworks incorporate spatial information to model ligand–receptor interactions and downstream signaling.
Yue-Song Wu, Hao-Hao Su, Yue-Hua Cui
· Briefings in Bioinformatics · 0 citations