Nigral DJ-1 gene knockout in tree shrews can induce phosphorylated α-synuclein aggregation and all key phenotypes of Parkinson’s disease
In vivo evidence is provided supporting a model in which DJ-1 deficiency can promote key PD-like phenotypes in tree shrews, potentially involving PSer129αSyn accumulation, nigral dopaminergic neuron loss, and motor dysfunction.
Hao Li, Leyi Mei, Jing-Mei Cha et al.
· Cell Death & Disease · 0 citations