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Open access Aug 2026

Haikunshenxi capsule alleviates renal fibrosis in chronic kidney disease via modulation of indoxyl Sulfate–Aryl hydrocarbon receptor signaling

Background Renal fibrosis, a common pathological endpoint in Chronic Kidney Disease (CKD), is closely associated with the accumulation of gut-derived uremic toxins, underscoring the therapeutic relevance of the gut-kidney axis. This study investigated the antifibrotic mechanism of Haikunshenxi Capsule (HKSX), a marine-...

Ping Li, Chong Chen, Bangjie Zuo et al. · 0 citations
Open access Aug 2026

Decoding macrophage-driven tumor heterogeneity in renal cell carcinoma using spatial and single-cell transcriptomics

Highlights • A macrophage-associated prognostic signature was developed for KIRC.• Prognostic genes were identified through Cox analysis and multi-algorithm screening.• An MRCS classifier was independently constructed using SLC11A1 and IFI30.• Survival stratification and validation were systematically performed.

Jing-Jing Duan, Xiang-Lin Liu, Fangmei Zeng et al. · 0 citations

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