Open access
Decoding macrophage-driven tumor heterogeneity in renal cell carcinoma using spatial and single-cell transcriptomics
Jing-Jing Duan
Xiang-Lin Liu
Fangmei Zeng
Hao Tang
Yuan-Jie Tang
Kai-Yi Lu
Le Qu
Wentao Zhang
Lin-Hui Wang
Jianfeng Yang
Yu-Ming Jin
Wenqiang Liu
Medicine
Abstract
Highlights • A macrophage-associated prognostic signature was developed for KIRC.• Prognostic genes were identified through Cox analysis and multi-algorithm screening.• An MRCS classifier was independently constructed using SLC11A1 and IFI30.• Survival stratification and validation were systematically performed.