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Open access Aug 2026

Decoding macrophage-driven tumor heterogeneity in renal cell carcinoma using spatial and single-cell transcriptomics

Highlights • A macrophage-associated prognostic signature was developed for KIRC.• Prognostic genes were identified through Cox analysis and multi-algorithm screening.• An MRCS classifier was independently constructed using SLC11A1 and IFI30.• Survival stratification and validation were systematically performed.

Jing-Jing Duan, Xiang-Lin Liu, Fangmei Zeng et al. · 0 citations
Open access Aug 2026

Genome-wide association study of sarcopenia index reveals sex-stratified genetic architecture

The sarcopenia index (SI), defined as the ratio of serum creatinine to cystatin C, is a proposed biomarker of muscle mass and sarcopenia, yet its genomic basis and genetic architecture remain largely unexplored. We performed combined-sex and sex-stratified genome-wide association studies of SI in the UK Biobank. We exa...

Yu-Meng Mu, Bin-Zhi Liao, Meng-Liang Luo et al. · 0 citations

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