Decoding macrophage-driven tumor heterogeneity in renal cell carcinoma using spatial and single-cell transcriptomics
Highlights • A macrophage-associated prognostic signature was developed for KIRC.• Prognostic genes were identified through Cox analysis and multi-algorithm screening.• An MRCS classifier was independently constructed using SLC11A1 and IFI30.• Survival stratification and validation were systematically performed.