Author

Hassan Fazilaty

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Open access Sep 2026

HOMEBRED: A unified CRISPR platform for field-ready shadowing of infectious agents and oncogenic mutations

Summary Emerging infectious diseases and late-stage cancers demand rapid, sensitive, and deployable diagnostics. Here, we present HOMEBRED (highly sensitive & specific omnipresent multipurpose endonuclease based reliable detection), a CRISPR-based platform capable of detecting human and animal pathogens (viral/bacteria...

Adnan Asadbeigi, Hassan Fazilaty, M. Saffari et al. · iScience · 0 citations

#protein folding Open access Sep 2026

APOA1 links a late fetal epithelial program to colonic maturation and injury responses

Developmental programs establish tissue identity and organization, but how their reactivation contributes to adult tissue responses remains poorly understood. Here, we identify a functional contribution of apolipoprotein A-I (APOA1), which marks a late fetal colonic epithelial state that reappears after injury. Spatial...

Aline Böniger, Valerie Georgette Katimi Varela, Dillon King et al. · bioRxiv · 0 citations

Review Open access Aug 2026

Emerging exposure-driven accelerated colorectal carcinogenesis: a model with implications for screening colonoscopy effectiveness.

Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide, with its burden projected to rise. Screening average-risk individuals is recommended because several strategies reduced CRC incidence and mortality. While overall CRC incidence and mortality have stabilised or declined in many de...

K. Truninger, Hariharan Easwaran, Finlay A. Macrae et al. · Gut · 0 citations