Preprint
Jul 2026
A quantitative model for the emergent population dynamics of the melanoma MITF rheostat
A multiscale phenotype-structured partial differential equation model for epidermal melanoma cell populations is developed, first considering subcellular MITF and then spatially uniform and spatially heterogeneous populations, highlighting that phenotype reversibility by individual cells does not imply reversibility of...
Keith L. Chambers, R. White, Colin R. Goding et al.
· 1 citation