Author

Hesham M. Hassan

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Sep 2026

Chronic labetalol exposure induced dose-dependent testicular toxicity via disruptingt HPG-axis, spermatogenesis and steroidogenic pathways: A biochemical, molecular and histopathological evidence.

Labetalol (LBL) is a combined-alpha and non-selective β-adrenergic receptor antagonist commonly prescribed for high blood pressure patients. However, LBL intoxication showed severe toxicity including testicular impairments. This experimental study aimed to elucidate the dose-responsive reproductive perturbations of LBL...

Salim Jamil, F. M. Alzahrani, Khalaf F. Alsharif et al. · Tissue & Cell · 0 citations

Aug 2026

Enhanced hepatoprotective effects of fisetin-loaded liposomal nanoparticles against DEHP-induced liver injury in rats: modulation of oxidative stress, inflammation, apoptosis, and ferroptosis pathways.

FSN-LNPs provided enhanced hepatoprotection against DEHP-induced toxicity compared with free FSN, which was associated with attenuation of oxidative stress and inflammation and modulation of apoptosis- and ferroptosis-related pathways, likely due to improved bioavailability and cellular delivery.

Ahmed Al-Emam, Hesham M. Hassan, E. Elmorsy et al. · Naunyn-Schmiedeberg's Archiv... · 0 citations

Aug 2026

Protective Effects of Icariin-Loaded Nanoliposomes against Methotrexate-Induced Testicular Toxicity via Modulation of NRF2/NF-κB and Ferroptosis Signaling.

ICA-loaded nanoliposomal formulation effectively attenuated MTX-induced testicular toxicity and was associated with reduced oxidative stress, inflammation, apoptosis, and ferroptosis, highlighting its potential as a promising therapeutic strategy for preserving male reproductive function.

Ahmed Al-Emam, Salim Jamil, Hesham M. Hassan et al. · Reproductive Toxicology · 0 citations