Enhanced hepatoprotective effects of fisetin-loaded liposomal nanoparticles against DEHP-induced liver injury in rats: modulation of oxidative stress, inflammation, apoptosis, and ferroptosis pathways.

Ahmed Al-Emam Hesham M. Hassan E. Elmorsy Ayat B. Al-Ghafari H. A. Al Doghaither Ahmed M. S. Hegazy Ola A Habota

Aug 2026 · Naunyn-Schmiedeberg's Archives of Pharmacology · 0 citations · 43 references

Medicine

TL;DR

FSN-LNPs provided enhanced hepatoprotection against DEHP-induced toxicity compared with free FSN, which was associated with attenuation of oxidative stress and inflammation and modulation of apoptosis- and ferroptosis-related pathways, likely due to improved bioavailability and cellular delivery.

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