Author

Hong Qian

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#gene editing Open access Oct 2026

A modular lentiviral system for multiplexed gene perturbation and functional analysis suggests interdependence of hormone receptors in breast cancer growth in vivo

A modular, doxycycline-inducible vector system that integrates gene overexpression, shRNA-mediated knockdown, and CRISPR/Cas9-mediated regulation within a single, lentivirus-compatible system that expands the experimental repertoire for dynamic, multigene interrogation in complex systems.

Seher Alam, Daria Matvienko, Johan Boström et al. · bioRxiv · 0 citations

Open access Oct 2026

Latexin deletion in the bone marrow niche suppresses leukemia via LIFR downregulation and immune activation.

Acute myeloid leukemia (AML) is the most common adult leukemia diagnosis. Bone marrow (BM) niche significantly influences the initiation and progression of AML. However, our knowledge about the effect of leukemic niche on leukemia stem cells (LSC) and leukemogenesis is limited. In this study, we identified an extrinsic...

Cui-Ping Zhang, Xia Yao, Pin-Pin Sui et al. · JCI Insight · 0 citations