How Does a Minimal Cell Maintain the Fidelity of Gene Expression? A Constraint-Space Perspective on Coordinated Transcription, Translation, and Protein Translocation
This is a Perspective article. Two recent Cell studies (Dobbs et al., 2026; Jensen et al., 2026) used in-cell cryo-electron tomography and visual proteomics in Mycoplasma pneumoniae to resolve structural coordination among transcription, translation, membrane translocation, and extracellular folding.We offer a theoreti...