Author

Howard Y. Chang

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Open access Sep 2026

Inverted logic of ecDNA localization converts nuclear periphery into oncogenic transcription hubs in cancer

Extrachromosomal DNA (ecDNA) is a major driver of cancer pathogenesis, however, its spatial organization in the nucleus is not currently understood. Here we show that ecDNAs, in contrast to chromosomal DNA, preferentially localize to the nuclear periphery yet resist peripheral gene silencing. Single-molecule multi-omic...

Yan-Bo Wang, Xiao-Wei Yan, Natasha E. Weiser et al. · bioRxiv · 0 citations

Jul 2026

Somatic mutations reveal the ontogeny of microglia in human ageing.

An approach that uses the collection of accumulated somatic mutations that uniquely labels each clone of cells to track the infiltration of bone-marrow-derived cells into the human brain finds evidence of an influx of bone-marrow-derived cells into the brain in all examined individuals.

Julia A. Belk, Yao-Wen Zhang, Emily E. Reilly et al. · Nature · 2 citations