Somatic mutations reveal the ontogeny of microglia in human ageing.

Julia A. Belk Yao-Wen Zhang Emily E. Reilly Quan-Ming Shi D. Liu Nicole L. Womack-Gambrel M. van der Linde Lisa Ma Debasmita Paul A. Enciso Raja Kalluru Jacob Weiss Rui Li Anna E. Eastman Chun-Fang Zhu Arnav Chakravarthy S. Bukhari Dipabarna Bhattacharya Suyash Raj Daniel Richard S. Brioschi Matthew R. Chrostek D. Nachun C. Arends J. Gopakumar Isak W. Tengesdal Ademar Bynum Shaneice R Mitchell Katalin D. Sandor Wen-Xin Zhang B. Vardarajan Inma Cobos Donald E. Born Robert B. West Anne Brunet Marco Colonna Krishna L. Bharani Hannes S. Vogel T. Montine C. Latimer Irving L. Weissman M. Matusiak Jody E. Hooper C. D. Keene Howard Y. Chang Siddhartha Jaiswal

Jul 2026 · Nature · 2 citations

Medicine

TL;DR

An approach that uses the collection of accumulated somatic mutations that uniquely labels each clone of cells to track the infiltration of bone-marrow-derived cells into the human brain finds evidence of an influx of bone-marrow-derived cells into the brain in all examined individuals.

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