Author

C. D. Keene

3 papers indexed here

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Open access Aug 2026

Aquaporin-4 mis-localization decreases glymphatic clearance of α-synuclein in an alpha-syntrophin knock out mouse model and promotes α-synuclein pathology and aggregate propagation.

The appearance of misfolded and aggregated proteins is a pathological hallmark of numerous neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Sleep disruption is proposed to contribute to these pathological processes and is a common early feature among neurodegenerative disorders. Synucle...

Molly Braun, Matthew J. Simon, Jay Jang et al. · Brain Communications · 0 citations

Jul 2026

Somatic mutations reveal the ontogeny of microglia in human ageing.

An approach that uses the collection of accumulated somatic mutations that uniquely labels each clone of cells to track the infiltration of bone-marrow-derived cells into the human brain finds evidence of an influx of bone-marrow-derived cells into the brain in all examined individuals.

Julia A. Belk, Yao-Wen Zhang, Emily E. Reilly et al. · Nature · 2 citations

#protein folding Open access Sep 2026

Single nucleus RNA sequencing and spatial transcriptomics reveal unique functionalities of gray matter versus white matter oligodendrocytes in aging and Alzheimer’s Disease

This analysis identified a conserved newly formed differentiating (NFOL)/differentiating → lipid remodeling → Stress/ISR-reactive architecture, with a pronounced expansion of the Stress/ISR-reactive compartment and altered transition-associated pathway enrichment in high ADNC WM.

Joseph P. Voth, Javier Ramos Benitez, Angela M. Wilson et al. · bioRxiv · 0 citations