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Author

Hung T. Nguyen

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Review Open access Sep 2026

Beyond RNA/DNA: exploring the emerging role of Poly(ADP-ribose): structure, function, and condensate formation

Poly(ADP-ribose) (PAR) is an RNA-like homopolymer synthesized by enzymes in response to DNA damage. Increasing evidence indicates that PAR participates in diverse cellular processes, in several cases by promoting or modulating biomolecular condensate formation. While condensate formation has been implicated in a variet...

Lipika Baidya, Hung T. Nguyen · 0 citations
Aug 2026

Molecular origins of heterogeneous aging and spatial organization in RNA condensates

It is demonstrated that aging is driven by sequence-encoded base pairing that favors RNA expansion, alignment and the formation of a dense interchain interaction network, establishing RNA sequence patterning as a key determinant not only of phase separation but also of condensate aging and spatial organization.

Dibyajyoti Mohanta, He-Yang Zhang, D. Thirumalai et al. · 0 citations

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