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Author

Hyun O. Lee

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Open access Aug 2026

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms

Deep long-read RNA sequencing and proteomics in induced pluripotent stem cell-derived cortical neurons is integrated to generate a high-resolution proteogenomic atlas of human neuron development, uncovering thousands of novel isoforms and revealing dynamic splicing changes in autism risk genes.

N. Xu, Katherine M. Rynard, E. Radley et al. · 1 citation
Aug 2026

PARP1 hyperactivity stalls translation and triggers stress granule formation following DNA damage.

Findings link PARP1 activity to translational control and SG formation, which may protect against cell death following DNA damage, and provide insight into PARP1- and stress granule-associated diseases, including cancer and neurodegeneration.

M. Tereshchenko, Rebecca Earnshaw, Christopher Chin Sang et al. · 0 citations

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