PARP1 hyperactivity stalls translation and triggers stress granule formation following DNA damage.

M. Tereshchenko Rebecca Earnshaw Christopher Chin Sang Minjung Won Jeanine L. Van Nostrand Ryan C. Russell Hyun O. Lee

Aug 2026 · Journal of Cell Biology · Vol 225 8 · 0 citations

Medicine

TL;DR

Findings link PARP1 activity to translational control and SG formation, which may protect against cell death following DNA damage, and provide insight into PARP1- and stress granule-associated diseases, including cancer and neurodegeneration.

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