Author

Ryan C. Russell

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Open access Sep 2026

45 Targeting Lysyl Oxidase Inhibits Tumor Progression in Clear Cell Renal Cell Carcinoma

Abstract Background Clear cell renal cell carcinoma (ccRCC) is defined by constitutive pseudohypoxia driven by von Hippel-Lindau (VHL) loss, pronounced intratumoral heterogeneity, and aberrant hypervascularity, features that collectively promote tumor progression and limit therapeutic durability. Although VEGF-targeted...

B. Ulukan, O. Saatci, A. Madrigal et al. · The Oncologist · 0 citations

Aug 2026

PARP1 hyperactivity stalls translation and triggers stress granule formation following DNA damage.

Findings link PARP1 activity to translational control and SG formation, which may protect against cell death following DNA damage, and provide insight into PARP1- and stress granule-associated diseases, including cancer and neurodegeneration.

M. Tereshchenko, Rebecca Earnshaw, Christopher Chin Sang et al. · Journal of Cell Biology · 0 citations

Open access Jul 2026

Lysyl oxidase drives ccRCC progression by coordinating HIF-2α transcription program with tumor microenvironment

Using single-cell transcriptomics, lysyl oxidase (LOX) is identified as a driver of ccRCC progression, selectively enriched in a hypoxia/epithelial-mesenchymal transition (EMT) gene program associated with poor outcome.

B. Ulukan, O. Saatci, A. Madrigal et al. · bioRxiv · 0 citations