Aug 2026
PARP1 hyperactivity stalls translation and triggers stress granule formation following DNA damage.
Findings link PARP1 activity to translational control and SG formation, which may protect against cell death following DNA damage, and provide insight into PARP1- and stress granule-associated diseases, including cancer and neurodegeneration.
M. Tereshchenko, Rebecca Earnshaw, Christopher Chin Sang et al.
· Journal of Cell Biology · 0 citations