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Author

I. Bozkurt

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Sep 2026

CUMYL-4CN-BINACA exposure is associated with oxidative stress, ER stress-related responses, apoptosis, and altered KIM-1, NGAL, and Nephrin expression in rat kidney.

CUMYL-4CN-BINACA (C-4CN-B), a potent synthetic cannabinoid (SC), is linked to severe systemic toxicity, but its renal molecular toxicity remains unclear. This study examined C-4CN-B-induced nephrotoxicity in male Sprague-Dawley rats, focusing on oxidative stress, inflammation, ER stress, and apoptosis. Thirty-two rats...

Esra Aktas Senocak, Ozkan Aksakal, Cihan Gür et al. · 0 citations
Aug 2026

Epigallocatechin-3-gallate as a hepatoprotective agent against ochratoxin a: modulating ER stress and NF-κB/TNF-α/IL-6 responses

It is demonstrated that OTA-induced hepatotoxicity may be mediated, at least in part, through modulation of ER stress and NF-κB-driven inflammatory cascades, and that EGCG demonstrated dose-dependent protection by attenuating these responses.

F. Yoladi, N. Demirtas, M. Sulak et al. · 0 citations
Jul 2026

Protective Effects of p-Coumaric Acid Against Lead-Induced Hepatic Oxidative Stress, Inflammation, and Apoptosis: Integrated Molecular and Machine Learning-Based Analysis.

Overall, PCA alleviates Pb-induced hepatotoxicity by restoring antioxidant defenses, suppressing inflammatory signalling, and inhibiting mitochondrial apoptotic pathways.

I. Bozkurt, Yeliz Demir, Tuba Karaarslan et al. · 1 citation

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